2. Others
  3. Isotope-Labeled Compounds
  4. 2583719-08-6

2583719-08-6

TyK2-IN-21-d3 Chemical Structure

2583719-08-6

Chemical Structure

  • TyK2-IN-21-d3
  • CAS No: 2583719-08-6
    Formula: C21H22D3N8O7P
    Molecular Weight: 535.46
  • InChIKey: LPGOZJVRCODLIY-UWRQEQCTSA-N
  • SMILES: O=P(O)(OCN1C=C(C(NC([2H])([2H])[2H])=O)C(NC2=CC=CC(C3=NN(C)N=N3)=C2OC)=C/C1=N\C(C4CC4)=O)O

Biological Activity: TyK2-IN-21-d3 (Compound 3c) is the orally active prodrug of the tyrosine kinase 2. TyK2-IN-21-d3 exhibits good chemical stability in aqueous system under different pHs. TyK2-IN-21-d3 alleviates the effect of gastric acid changes on drug absorption and improve the drug bioavailability in rat model[1].

Cat. No. Product Name Purity Description
HY-169986S TyK2-IN-21-d3 TyK2-IN-21-d3 (Compound 3c) is the orally active prodrug of the tyrosine kinase 2. TyK2-IN-21-d3 exhibits good chemical stability in aqueous system under different pHs. TyK2-IN-21-d3 alleviates the effect of gastric acid changes on drug absorption and improve the drug bioavailability in rat model.

References

[1]. A M Subbaiah M, et al., Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent. J Med Chem. 2024 Nov 28;67(22):20664-20681. [Content Brief]

Keywords:

TyK2-IN-21-d3