2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. 1997319-84-2

1997319-84-2

SGC-SMARCA-BRDVIII Chemical Structure

1997319-84-2

Chemical Structure

  • SGC-SMARCA-BRDVIII
  • CAS No: 1997319-84-2
    Formula: C19H25N5O3
    Molecular Weight: 371.43
  • IUPAC Name: tert-butyl 4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazine-1-carboxylate
  • InChIKey: AQTNUGRRZDRZIA-UHFFFAOYSA-N
  • SMILES: O=C(N1CCN(CC1)C2=C(N)N=NC(C3=CC=CC=C3O)=C2)OC(C)(C)C

Biological Activity: SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].

Cat. No. Product Name Purity Description
HY-145446 SGC-SMARCA-BRDVIII 99.92% SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts.

References

[1]. Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63(23):14680-14699. [Content Brief]
[2]. Mélin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6(33):21327-21338. [Content Brief]

Keywords:

SGC-SMARCA-BRDVIII