2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. 133156-06-6

133156-06-6

GR-73632 Chemical Structure

133156-06-6

Chemical Structure

  • GR-73632
  • CAS No: 133156-06-6
    Formula: C40H59N7O6S
    Molecular Weight: 766.00
  • IUPAC Name: (S)-N-((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-((5-aminopentanoyl)-L-phenylalanyl-L-phenylalanyl)-N-methylpyrrolidine-2-carboxamide
  • InChIKey: HQKPTSSZOJLFBZ-LJADHVKFSA-N
  • SMILES: NCCCCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N([C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)C)=O)=O)=O)=O

Biological Activity: GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2].

Cat. No. Product Name Purity Description
HY-P1192 GR-73632 99.93% GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

References

[1]. Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20(2):301-4. [Content Brief]
[2]. Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24(4):312-4. [Content Brief]

Keywords:

GR-73632