MHC

Major Histocompatibility Complex; MHC

MHC is a group of genes encoding proteins which are transferred to the cell surfaces to present the intracellular or extracellular, self or non-self antigens to the cells of the immune system, thereby helping T cells in differentiating self from non-self proteins, and initiating adaptive immune responses. MHC can be divided into 3 subtypes, MHC I, MHC II and MHC III, in which MHC I presents endogenous antigens (such as antigens produced by virus-infected cells or tumor cells) to activate cytotoxic T cells (CD8+ T cells); MHC II presents exogenous antigens (such as bacteria or parasites) to activate helper T cells (CD4+ T cells); MHC III does not directly participate in antigen presentation, but involves in immune regulation, inflammatory response and cell signaling. MHC is crucial for stem cell transplant (SCT), and could lead to graft-versus-host disease (GVHD)^[1]^[2].

References:

[1]. Deakin JE, et al., Evolution and comparative analysis of the MHC Class III inflammatory region. BMC Genomics. 2006 Nov 2;7:281. [Content Brief]

[2]. Sharma S K. Major Histocompatibility Complex[M]//Basics of Hematopoietic Stem Cell Transplant. Singapore: Springer Nature Singapore, 2023: 903-913.

MHC Related Products (17):

By Effects:	Ligand (1) Inhibitors (5) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P1587

IRBP (1-20), human		99.65%
IRBP (1-20), human contains a major epitope for the H-2^b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2^b mice.

HY-P2459

MOG (35-55), human		98.51%
MOG (35-55), human is a component of CNS myelin. MOG (35-55), human is different from mMOG (35-55) by a proline for serine substitution at position 42. MOG (35-55), human is also immunogenic via bind to H-2b class II MHC and recognized by T cells, but not encephalitogenic, and is only partially cross-reactive with mMOG35–55. MOG (35-55), human induces minimal clinical signs of EAE relative to the rodent peptide.

HY-P1585

Gp100 (25-33), human		99.28%
Gp100 (25-33), human (Hgp100 (25-33)) is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2D^b and recognized by the T cells.

HY-P990189

Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243)	Inhibitor
Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to monkey/human MHC class II.

HY-P2461

MOG (89-113), human
MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.

HY-P10840

Tkip	Inhibitor
Tkip is a JAK2 specific inhibitor. Tkip can bind the JAK2 autophosphorylation site, inhibit the JAK2 autophosphorylation and the phosphorylation of the IFN-γ receptor subunit IFNGR-1. Tkip inhibits the antiviral activity of IFN-γ and the expression of MHC Class I molecules. Tkip can be used to study the IFN-γ signaling pathway.

HY-P2525

GAD65 (206-220)
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus.

HY-P990185

Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S)	Inhibitor
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse/rat MHC Class II.

HY-P5966

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse
Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a CD8-related self-antigenic epitope of the myelin oligodendrocyte glycoprotein (MOG) protein and is presented in association with H-2Db.

HY-P10246

Hemoglobin (64-76)
Hemoglobin 64-76 is a T cell inducing determinant, that binds to two different MHC class II molecules in distinct registers and lengths.

HY-P990140

Anti-Rat β-2-Microglobulin Antibody (4C9)
Anti-Rat β-2-Microglobulin Antibody (4C9) is a mouse-derived IgG1 type antibody inhibitor, targeting to rat β-2-Microglobulin.

HY-P990184

Anti-Mouse MHC Class II (βchain) Antibody (KL277)	Inhibitor
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II.

HY-P10382

M133 peptide
M133 peptide is a coronavirus-specific CD4 T cell epitope. M133 peptide is immunodominant in mice infected with the neurotropic coronavirus (the JHM strain of mouse hepatitis virus). M133 peptide forms a complex with MHC II molecules, which is recognized by specific TCRs, thereby activating CD4 T cells.

HY-P5499

CMV pp65(13-27)	Ligand
CMV pp65(13-27) is a biological active peptide. (This peptide is derived from amino acid residues 13 to 27 of the 65k lower matrix phosphoprotein of the human cytomegalovirus. It contains a nine-amino-acid sequence (LGPISGHVL) that matches the consensus binding motif for a major histocompatibility complex H2-Dd T-cell epitope.)

HY-157171

Ac-YR-NH2	Modulator
Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response.

HY-157280

AdCaPy
AdCaPy is an MHC II antigen loading catalyst that accelerates the loading of peptide antigens by MHC II. AdCaPy is a useful molecular tool for enhancing immune responses.

HY-P990832

Anti-MHC Class I Antibody (W6/32)	Inhibitor
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a, κ chimeric antibody, targeting to human MHC Class I. The recommend isotype control of Anti-MHC Class I Antibody (W6/32): Mouse IgG2a kappa, Isotype Control (HY-P99978).

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