2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. 1350884-56-8

1350884-56-8

(3aR)-Selitrectinib Chemical Structure

1350884-56-8

Chemical Structure

  • (3aR)-Selitrectinib
  • Synonym(s): (3aR)-LOXO-195
  • CAS No: 1350884-56-8
    Formula: C20H21FN6O
    Molecular Weight: 380.42
  • IUPAC Name: (13E,14E,22R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one
  • InChIKey: OEBIHOVSAMBXIB-RGUGMKFQSA-N
  • SMILES: FC1=CN=C(CCC(N2)C)C([C@](CCC3)([H])N3C(C=CN4N=C5)=NC4=C5C2=O)=C1

Biological Activity: (3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].

Cat. No. Product Name Purity Description
HY-101977B (3aR)-Selitrectinib (3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.

References

[1]. Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972. [Content Brief]

Keywords:

(3aR)-Selitrectinib