2. Natural Products
  3. Plants Terpenoids
  4. Sapindaceae Diterpenoids
  5. Dodonaea viscosa (L.) Jacq.
  6. 2735645-53-9

2735645-53-9

PARP1-IN-5 Chemical Structure

2735645-53-9

Chemical Structure

  • PARP1-IN-5
  • CAS No: 2735645-53-9
    Formula: C25H24N2O5S
    Molecular Weight: 464.53
  • IUPAC Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-((4-(thiophen-2-ylmethyl)piperazin-1-yl)methyl)-4H-chromen-4-one
  • InChIKey: RNPMZVGNPDWZAV-UHFFFAOYSA-N
  • SMILES: O=C1C=C(OC2=C1C(O)=CC(O)=C2CN3CCN(CC3)CC4=CC=CS4)C5=CC=C(C=C5)O

Biological Activity: PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 can be used for the research of cancer[1].

Cat. No. Product Name Purity Description
HY-138215 ADTL-EI1712 ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo.

References

[1]. Long H, et al. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. J Med Chem. 2021;64(16):12089-12108. [Content Brief]

Keywords:

PARP1-IN-5