2. Apoptosis
  3. Apoptosis
  4. 2545963-24-2

2545963-24-2

Lenalidomide-5-bromopentanamide Chemical Structure

2545963-24-2

Chemical Structure

  • Lenalidomide-5-bromopentanamide
  • CAS No: 2545963-24-2
    Formula: C18H20BrN3O4
    Molecular Weight: 422.27
  • InChIKey: ACCSPOFIPHGKAW-UHFFFAOYSA-N
  • SMILES: BrCCCCC(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)=O

Biological Activity: Lenalidomide-5-bromopentanamide is an E3 ligase ligand-linker conjugate in PROTAC ATR degrader-2 (HY-161615), and consists of a CRBN ligand Lenalidomide (HY-A0003) and a linker 5-Bromopentanoyl chloride (HY-43538). Lenalidomide-5-bromopentanamidecan be used for synthesis of PROTACs[1].

Cat. No. Product Name Purity Description
HY-161675 Lenalidomide-5-bromopentanamide Lenalidomide-5-bromopentanamide is an E3 ligase ligand-linker conjugate in PROTAC ATR degrader-2 (HY-161615), and consists of a CRBN ligand Lenalidomide (HY-A0003) and a linker 5-Bromopentanoyl chloride (HY-43538). Lenalidomide-5-bromopentanamidecan be used for synthesis of PROTACs.

References

[1]. Wang Y, et al. Discovery of Selective and Potent ATR Degrader for Exploration its Kinase-Independent Functions in Acute Myeloid Leukemia Cells. Angew Chem Int Ed Engl. 2024 Apr 22;63(17):e202318568. [Content Brief]

Keywords:

Lenalidomide-5-bromopentanamide