2. PROTAC Cell Cycle/DNA Damage Autophagy Apoptosis Immunology/Inflammation
  3. Ligands for Target Protein for PROTAC FKBP
  4. 1454299-21-8

1454299-21-8

TP-004 Chemical Structure

1454299-21-8

Chemical Structure

  • TP-004
  • CAS No: 1454299-21-8
    Formula: C17H16F3N5O
    Molecular Weight: 363.34
  • IUPAC Name: (R)-1-(4-methyl-5-(6-(trifluoromethyl)-1H-indazol-4-yl)pyrimidin-2-yl)pyrrolidin-3-ol
  • InChIKey: BNTAEJNPQLMGDJ-LLVKDONJSA-N
  • SMILES: O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1

Biological Activity: TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1].

Cat. No. Product Name Purity Description
HY-120868 TP-004 98.89% TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM.

References

[1]. Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26(12), 2774–2778.

Keywords:

TP-004