2. PROTAC Neuronal Signaling
  3. PROTACs Tau Protein
  4. 2267290-96-8

2267290-96-8

QC-01–175 Chemical Structure

2267290-96-8

Chemical Structure

  • QC-01–175
  • CAS No: 2267290-96-8
    Formula: C33H34N6O7
    Molecular Weight: 626.66
  • IUPAC Name: N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide
  • InChIKey: NWTCZTAQSRLSCP-UHFFFAOYSA-N
  • SMILES: O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC4=CC5=C(C=C4)C(C=NC=C6)=C6N5

Biological Activity: QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2].

References

[1]. Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457. [Content Brief]
[2]. Tiziana Petrozziello, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan;59(1):683-702. [Content Brief]

Keywords:

QC-01–175