2. PROTAC
  3. PROTAC Linkers
  4. 2353409-72-8

2353409-72-8

N-(DBCO-PEG4)-N-Biotin-PEG4-NHS Chemical Structure

2353409-72-8

Chemical Structure

  • N-(DBCO-PEG4)-N-Biotin-PEG4-NHS
  • CAS No: 2353409-72-8
    Formula: C54H74N6O16S
    Molecular Weight: 1095.26
  • InChIKey: WGXIBGJQQHWGKY-XVESOEPISA-N
  • SMILES: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN(C(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O)CCOCCOCCOCCOCCNC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O

Biological Activity: N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Cat. No. Product Name Purity Description
HY-140582 N-(DBCO-PEG4)-N-Biotin-PEG4-NHS N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Keywords:

N-(DBCO-PEG4)-N-Biotin-PEG4-NHS