2. Apoptosis
  3. RIP kinase
  4. 2987760-64-3

2987760-64-3

Mt KARI-IN-1 Chemical Structure

2987760-64-3

Chemical Structure

  • Mt KARI-IN-1
  • CAS No: 2987760-64-3
    Formula: C14H11N5O4S2
    Molecular Weight: 377.40
  • IUPAC Name: 1-(4-methoxyphenyl)-3-(5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)urea
  • InChIKey: NCGHEDQKUUEBRW-UHFFFAOYSA-N
  • SMILES: COC1=CC=C(C=C1)NC(NC2=NN=C(S2)C3=CC=C(S3)[N+]([O-])=O)=O

Biological Activity: Mt KARI-IN-1 (Lead compound) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 3.06 μM[1].

Cat. No. Product Name Purity Description
HY-146298 Mt KARI-IN-1 Mt KARI-IN-1 (Lead compound) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 3.06 μM.

References

[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178. [Content Brief]

Keywords:

Mt KARI-IN-1