2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. 1438072-11-7

1438072-11-7

Larotinib Chemical Structure

1438072-11-7

Chemical Structure

  • Larotinib
  • CAS No: 1438072-11-7
    Formula: C24H26ClFN4O4
    Molecular Weight: 488.94
  • IUPAC Name: N-(3-chloro-4-fluorophenyl)-6-(3-((4aR,7aS)-hexahydro-6H-[1,4]dioxino[2,3-c]pyrrol-6-yl)propoxy)-7-methoxyquinazolin-4-amine
  • InChIKey: UFUKZMIXTOMMLU-ZRZAMGCNSA-N
  • SMILES: COC(C(OCCCN1C[C@]2([H])[C@](OCCO2)([H])C1)=C3)=CC4=C3C(NC5=CC(Cl)=C(C=C5)F)=NC=N4

Biological Activity: Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM[1].

Cat. No. Product Name Purity Description
HY-153110 Larotinib 99.50% Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM.

References

[1]. Liu J, et al. Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients With Advanced Solid Tumors. Front Pharmacol. 2021 Feb 18;12:636324. [Content Brief]

Keywords:

Larotinib