2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. 1807913-16-1

1807913-16-1

J147 Chemical Structure

1807913-16-1

Chemical Structure

  • J147
  • CAS No: 1807913-16-1
    Formula: C18H17F3N2O2
    Molecular Weight: 350.33
  • InChIKey: HYMZAYGFKNNHDN-SSDVNMTOSA-N
  • SMILES: COC1=CC=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=C1

Biological Activity: J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD)[1].

Cat. No. Product Name Purity Description
HY-13779A J147 99.90% J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD).

References

[1]. Kyoungdo Kim, et al. Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem. 2015 Oct 7;13(37):9564-9. [Content Brief]

Keywords:

J147