2. Anti-infection
  3. SARS-CoV
  4. 2722634-95-7

2722634-95-7

SARS-CoV-2-IN-10 Chemical Structure

2722634-95-7

Chemical Structure

  • SARS-CoV-2-IN-10
  • CAS No: 2722634-95-7
    Formula: C27H37F2N3O5
    Molecular Weight: 521.60
  • IUPAC Name: (4,4-difluorocyclohexyl)(phenyl)methyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate
  • InChIKey: QMWZWHYKVZAETM-FDWBJODVSA-N
  • SMILES: O=C(NCC1)[C@@H]1C[C@@H](C=O)NC([C@H](CC(C)C)NC(OC(C2=CC=CC=C2)C3CCC(F)(CC3)F)=O)=O

Biological Activity: SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

Cat. No. Product Name Purity Description
HY-145276 SARS-CoV-2-IN-10 SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.

References

[1]. Dampalla CS, et al. Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies. J Med Chem. 2021;64(24):17846-17865. [Content Brief]

Keywords:

SARS-CoV-2-IN-10