2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-10

SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.

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SARS-CoV-2-IN-10 Chemical Structure

SARS-CoV-2-IN-10 Chemical Structure

CAS No. : 2722634-95-7

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Description

SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

IC50 & Target

SARS-CoV-2 3C-like protease[1]
Cellular Effect
Cell Line Type Value Description References
HEK-293T CC50
> 100 μM
Compound: 15b
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
[PMID: 34865476]
Molecular Weight

521.60

Formula

C27H37F2N3O5
CAS No.
SMILES

O=C(NCC1)[C@@H]1C[C@@H](C=O)NC([C@H](CC(C)C)NC(OC(C2=CC=CC=C2)C3CCC(F)(CC3)F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2-IN-10 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SARS-CoV-2-IN-102722634-95-7SARS-CoVSARS coronavirusnontoxicSARS-CoV-2 3CL protease3CLproantiviralInhibitorinhibitorinhibit

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