2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. 204460-24-2

204460-24-2

NK3201 Chemical Structure

204460-24-2

Chemical Structure

  • NK3201
  • CAS No: 204460-24-2
    Formula: C31H29N5O6
    Molecular Weight: 567.59
  • IUPAC Name: N-(3,4-dioxo-1-phenyl-7-(pyridin-2-yloxy)heptan-2-yl)-2-(5-formamido-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetamide
  • InChIKey: QOANBAXBOLUAFA-UHFFFAOYSA-N
  • SMILES: O=C(NC(CC1=CC=CC=C1)C(C(CCCOC2=NC=CC=C2)=O)=O)CN(C(C3=CC=CC=C3)=NC=C4NC=O)C4=O

Biological Activity: NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein[1][2].

Cat. No. Product Name Purity Description
HY-12514 NK3201 NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein.

References

[1]. Sakaguchi M, et al. A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters. Eur J Pharmacol. 2004 Jun 16;493(1-3):173-6. [Content Brief]
[2]. Takai S, et al. Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein. Life Sci. 2001 Aug 31;69(15):1725-32. [Content Brief]

Keywords:

NK3201