2. GPCR/G Protein Neuronal Signaling Autophagy Immunology/Inflammation MAPK/ERK Pathway Apoptosis
  3. Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase
  4. 28094-15-7

28094-15-7

Oxidopamine hydrochloride Chemical Structure

28094-15-7

Chemical Structure

  • Oxidopamine hydrochloride
  • Synonym(s): 6-Hydroxydopamine Hydrochloride
  • CAS No: 28094-15-7
    Formula: C8H12ClNO3
    Molecular Weight: 205.64
  • IUPAC Name: 5-(2-aminoethyl)benzene-1,2,4-triol hydrochloride
  • InChIKey: QLMRJHFAGVFUAC-UHFFFAOYSA-N
  • SMILES: OC1=CC(CCN)=C(O)C=C1O.[H]Cl

Biological Activity: Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome[1][2][3][4].

Cat. No. Product Name Purity Description
HY-B1081 Oxidopamine hydrochloride 99.71% Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.

References

[1]. Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. [Content Brief]
[2]. Jin F, et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol. 2008 Dec 14;600(1-3):78-82. [Content Brief]
[3]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23. [Content Brief]
[4]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12. [Content Brief]

Keywords:

Oxidopamine hydrochloride