2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Monoamine Oxidase
  4. 2986222-45-9

2986222-45-9

5-HT6R/MAO-B modulator 1 Chemical Structure

2986222-45-9

Chemical Structure

  • 5-HT6R/MAO-B modulator 1
  • CAS No: 2986222-45-9
    Formula: C34H40N4O3S
    Molecular Weight: 584.77
  • IUPAC Name: N-methyl-N-(4-((5-(4-(1-(phenylsulfonyl)-1H-indol-4-yl)piperazin-1-yl)pentyl)oxy)benzyl)prop-2-yn-1-amine
  • InChIKey: CUFJQHNVDRIQJL-UHFFFAOYSA-N
  • SMILES: CN(CC#C)CC1=CC=C(C=C1)OCCCCCN2CCN(CC2)C3=C4C=CN(C4=CC=C3)S(=O)(C5=CC=CC=C5)=O

Biological Activity: 5-HT6R/MAO-B modulator 1 (compound 48) is an antagonist of 5-HT6R at Gs signaling and an irreversible MAO-B inhibitor. 5-HT6R/MAO-B modulator 1 exhibits glioprotective properties. 5-HT6R/MAO-B modulator 1 can reverse Scopolamine-induced memory deficits[1]. 5-HT6R/MAO-B modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No. Product Name Purity Description
HY-146677 5-HT6R/MAO-B modulator 1 5-HT6R/MAO-B modulator 1 (compound 48) is an antagonist of 5-HT6R at Gs signaling and an irreversible MAO-B inhibitor. 5-HT6R/MAO-B modulator 1 exhibits glioprotective properties. 5-HT6R/MAO-B modulator 1 can reverse Scopolamine-induced memory deficits. 5-HT6R/MAO-B modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1]. Canale V, et, al. A dual-acting 5-HT 6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties. Eur J Med Chem. 2020 Dec 15;208:112765. [Content Brief]

Keywords:

5-HT6R/MAO-B modulator 1