2. 1215621-31-0

1215621-31-0

Sumatriptan-d<sub>6</sub> succinate Chemical Structure

1215621-31-0

Chemical Structure

  • Sumatriptan-d6 succinate
  • Synonym(s): GR 43175C-d6
  • CAS No: 1215621-31-0
    Formula: C18H21D6N3O6S
    Molecular Weight: 419.53
  • IUPAC Name: 1-(3-(2-(bis(methyl-d3)amino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide succinate
  • InChIKey: PORMUFZNYQJOEI-HVTBMTIBSA-N
  • SMILES: OC(CCCC(CC(O)=O)C(O)=O.C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])C=1C=2C(NC1)=CC=C(CS(NC)(=O)=O)C2

Biological Activity: Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research[1][2][3].

Cat. No. Product Name Purity Description
HY-B0121BS Sumatriptan-d6 succinate 99.63% Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research.
HY-B0121R Sumatriptan (succinate) (Standard) ≥98% Sumatriptan (succinate) (Standard) is the analytical standard of Sumatriptan (succinate). This product is intended for research and analytical applications. Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research.
HY-B0121 Sumatriptan succinate 99.94% Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan succinate can be used for migraine headache research.

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163(1):133-6. [Content Brief]
[3]. K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43(5):776-98. [Content Brief]

Keywords:

Sumatriptan-d6 succinateSumatriptan (succinate) (Standard)Sumatriptan succinate