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  4. 5614-64-2

5614-64-2

8-Hydroxyguanine Chemical Structure

5614-64-2

Chemical Structure

  • 8-Hydroxyguanine
  • CAS No: 5614-64-2
    Formula: C5H5N5O2
    Molecular Weight: 167.13
  • IUPAC Name: 2-amino-7,9-dihydro-1H-purine-6,8-dione
  • InChIKey: CLGFIVUFZRGQRP-UHFFFAOYSA-N
  • SMILES: O=C1NC(N)=NC2=C1NC(N2)=O

Biological Activity: 8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2].

Cat. No. Product Name Purity Description
HY-113338 8-Hydroxyguanine 98.37% 8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage.

References

[1]. Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6. [Content Brief]
[2]. Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel). 2023 Jun 19;12(6):1300.

Keywords:

8-Hydroxyguanine