2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. 466-06-8

466-06-8

Proscillaridin A Chemical Structure

466-06-8

Chemical Structure

  • Proscillaridin A
  • CAS No: 466-06-8
    Formula: C30H42O8
    Molecular Weight: 530.65
  • IUPAC Name: 5-((3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
  • InChIKey: MYEJFUXQJGHEQK-ALRJYLEOSA-N
  • SMILES: O[C@@]([C@@]1(CC2)C)(CC[C@@H]1C(C=C3)=COC3=O)[C@@](CCC4=C[C@@H](O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)CC6)([H])[C@@]2([H])[C@]46C

Biological Activity: Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1].

Cat. No. Product Name Purity Description
HY-N2331R Proscillaridin A (Standard) ≥98% Proscillaridin A (Standard) is the analytical standard of Proscillaridin A. This product is intended for research and analytical applications. Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
HY-N2331 Proscillaridin A ≥99.0% Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.

References

[1]. Bielawski K, et al. Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.Biol Pharm Bull. 2006 Jul;29(7):1493-7. [Content Brief]

Keywords:

Proscillaridin A (Standard)Proscillaridin A