2. GPCR/G Protein Stem Cell/Wnt JAK/STAT Signaling Immunology/Inflammation
  3. CXCR STAT
  4. 51005-44-8

51005-44-8

Minecoside Chemical Structure

51005-44-8

Chemical Structure

  • Minecoside
  • CAS No: 51005-44-8
    Formula: C25H30O13
    Molecular Weight: 538.50
  • IUPAC Name: (1aS,1bS,2S,5aR,6S,6aS)-1a-(hydroxymethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl (E)-3-(3-hydroxy-4-methoxyphenyl)acrylate
  • InChIKey: LRHHPZILMPIMIY-GGKKSNITSA-N
  • SMILES: OC[C@@]1([C@]([C@@H]2O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)([H])[C@](C=CO2)([H])[C@@H]4OC(/C=C/C(C=C5)=CC(O)=C5OC)=O)[C@@]4([H])O1

Biological Activity: Minecoside is a CXCR4/STAT3 inhibitor with anticancer and anti-inflammatory activity. Minecoside decreases CXCR4 expression and suppresses STAT3 activation, thus to inhibit CXCL 12-induced invasion. Minecoside potently inhibits cancer metastasis and promotes apoptotic progression[1][2].

Cat. No. Product Name Purity Description
HY-N3255 Minecoside 99.86% Minecoside is a CXCR4/STAT3 inhibitor with anticancer and anti-inflammatory activity. Minecoside decreases CXCR4 expression and suppresses STAT3 activation, thus to inhibit CXCL 12-induced invasion. Minecoside potently inhibits cancer metastasis and promotes apoptotic progression.

References

[1]. Kim B, et al. Minecoside Modulates Cell Invasion via Regulation of CXCR4 Expression in Breast and Colon Cancer Cells. Planta Med. 2020 Mar;86(5):331-337. [Content Brief]
[2]. Kim B, et al. Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells. Oncol Lett. 2022 Mar;23(3):94. [Content Brief]

Keywords:

Minecoside