2. GPCR/G Protein Stem Cell/Wnt JAK/STAT Signaling Immunology/Inflammation
  3. CXCR STAT
  4. Minecoside

Minecoside is a CXCR4/STAT3 inhibitor with anticancer and anti-inflammatory activity. Minecoside decreases CXCR4 expression and suppresses STAT3 activation, thus to inhibit CXCL 12-induced invasion. Minecoside potently inhibits cancer metastasis and promotes apoptotic progression.

For research use only. We do not sell to patients.

Minecoside Chemical Structure

Minecoside Chemical Structure

CAS No. : 51005-44-8

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1 mg USD 180 In-stock
5 mg USD 450 Get quote
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Based on 1 publication(s) in Google Scholar

Minecoside Related Antibodies

Top Publications Citing Use of Products

View All CXCR Isoform Specific Products:

View All Isoforms
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

View All STAT Isoform Specific Products:

View All Isoforms
STAT3 STAT5 STAT6 STAT1

  • Biological Activity

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Description

Minecoside is a CXCR4/STAT3 inhibitor with anticancer and anti-inflammatory activity. Minecoside decreases CXCR4 expression and suppresses STAT3 activation, thus to inhibit CXCL 12-induced invasion. Minecoside potently inhibits cancer metastasis and promotes apoptotic progression[1][2].

IC50 & Target

CXCR4; STAT3
Molecular Weight

538.50

Formula

C25H30O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@]1([C@]([C@@H]2O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)([H])[C@](C=CO2)([H])[C@@H]4OC(/C=C/C(C=C5)=CC(O)=C5OC)=O)[C@@]4([H])O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 5.5 mg/mL (10.21 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8570 mL 9.2851 mL 18.5701 mL
5 mM 0.3714 mL 1.8570 mL 3.7140 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8570 mL 9.2851 mL 18.5701 mL 46.4253 mL
5 mM 0.3714 mL 1.8570 mL 3.7140 mL 9.2851 mL
10 mM 0.1857 mL 0.9285 mL 1.8570 mL 4.6425 mL
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Minecoside Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Minecoside51005-44-8CXCRSTATCXC chemokine receptorsC-X-C motif chemokine receptorsanticanceranti-inflammatoryInhibitorinhibitorinhibit

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