2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. 52238-35-4

52238-35-4

9-Hydroxyellipticine hydrochloride Chemical Structure

52238-35-4

Chemical Structure

  • 9-Hydroxyellipticine hydrochloride
  • CAS No: 52238-35-4
    Formula: C17H15ClN2O
    Molecular Weight: 298.77
  • IUPAC Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol hydrochloride
  • InChIKey: DLDKVFOKLGPVBT-UHFFFAOYSA-N
  • SMILES: OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1.[H]Cl

Biological Activity: 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].

Cat. No. Product Name Purity Description
HY-101775A 9-Hydroxyellipticine hydrochloride ≥99.0% 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively.

References

[1]. Renault G, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):281-6.
[2]. Saeki K, et al. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89(1):21-8. [Content Brief]
[3]. G Renault, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):281-6. [Content Brief]

Keywords:

9-Hydroxyellipticine hydrochloride