2. PI3K/Akt/mTOR
  3. PI3K
  4. 6318-41-8

6318-41-8

AS-041164 Chemical Structure

6318-41-8

Chemical Structure

  • AS-041164
  • CAS No: 6318-41-8
    Formula: C11H7NO4S
    Molecular Weight: 249.24
  • IUPAC Name: (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
  • InChIKey: SDGWAUUPHUBJNQ-WTKPLQERSA-N
  • SMILES: O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2

Biological Activity: AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects[1].

Cat. No. Product Name Purity Description
HY-118521 AS-041164 99.02% AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects.

References

[1]. Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322(3):923-30. [Content Brief]

Keywords:

AS-041164