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  4. 171674-76-3

171674-76-3

Bis-T-23 Chemical Structure

171674-76-3

Chemical Structure

  • Bis-T-23
  • Synonym(s): AG1717
  • CAS No: 171674-76-3
    Formula: C23H20N4O8
    Molecular Weight: 480.43
  • IUPAC Name: (2E,2'E)-N,N'-(propane-1,3-diyl)bis(2-cyano-3-(3,4,5-trihydroxyphenyl)acrylamide)
  • InChIKey: AAPVOSBVTLGGOU-VHUAAIQRSA-N
  • SMILES: O=C(/C(C#N)=C/C1=CC(O)=C(C(O)=C1)O)NCCCNC(/C(C#N)=C/C2=CC(O)=C(C(O)=C2)O)=O

Biological Activity: Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].

Cat. No. Product Name Purity Description
HY-123572 Bis-T-23 96.07% Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD).

References

[1]. Schiffer M, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21(6):601-609. [Content Brief]
[2]. Mazumder, A.,et al. Effects of Tyrphostins, Protein Kinase Inhibitors, on Human Immunodeficiency Virus Type 1 Integrase. Biochemistry, 1995, 34(46), 15111–15122.

Keywords:

Bis-T-23