2. Metabolic Enzyme/Protease
  3. ATP Citrate Lyase Acyltransferase Endogenous Metabolite
  4. 2338793-00-1

2338793-00-1

SH379 Chemical Structure

2338793-00-1

Chemical Structure

  • SH379
  • CAS No: 2338793-00-1
    Formula: C23H29N3O2
    Molecular Weight: 379.50
  • IUPAC Name: (6aR,12aS)-2-methoxy-N,7,7,9,12a-pentamethyl-5,6,6a,7,12,12a-hexahydronaphtho[1,2-g]quinazoline-3-carboxamide
  • InChIKey: MYOHHONXVHHTGT-WMZHIEFXSA-N
  • SMILES: C[C@@]12C3=CC(OC)=C(C(NC)=O)C=C3CC[C@@]1([H])C(C)(C4=NC(C)=NC=C4C2)C

Biological Activity: SH379 is the derivative of 2-methylpyrimidine-fused tricyclic diterpene. SH379 is a potent and orally active anti-late-onset hypogonadism agent. SH379 significantly promotes the expression of the key testosterone synthesis-related enzymes StAR and 3β-HSD. SH379 stimulates autophagy through regulating AMPK/mTOR signaling pathway[1].

Cat. No. Product Name Purity Description
HY-143656 SH379 SH379 is the derivative of 2-methylpyrimidine-fused tricyclic diterpene. SH379 is a potent and orally active anti-late-onset hypogonadism agent. SH379 significantly promotes the expression of the key testosterone synthesis-related enzymes StAR and 3β-HSD. SH379 stimulates autophagy through regulating AMPK/mTOR signaling pathway.

References

[1]. Bai J, et al. Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents. Eur J Med Chem. 2019;176:21-40. [Content Brief]

Keywords:

SH379