2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. 354812-16-1

354812-16-1

AA43279 Chemical Structure

354812-16-1

Chemical Structure

  • AA43279
  • CAS No: 354812-16-1
    Formula: C12H12N2O2S
    Molecular Weight: 248.31
  • IUPAC Name: 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
  • InChIKey: OEUITKOCUWEFOB-UHFFFAOYSA-N
  • SMILES: O=C(C1=C(N)C=C(C2=CC=C(OC)C=C2)S1)N

Biological Activity: AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model[1].

Cat. No. Product Name Purity Description
HY-125928 AA43279 AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model.

References

[1]. Frederiksen K, et al., A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo. Eur J Neurosci. 2017 Aug;46(3):1887-1896. [Content Brief]

Keywords:

AA43279