2. Stem Cell/Wnt JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. STAT VEGFR Bcl-2 Family Survivin IAP
  4. 220339-00-4

220339-00-4

N-Pentanoyl 2-benzyltryptamine Chemical Structure

220339-00-4

Chemical Structure

  • N-Pentanoyl 2-benzyltryptamine
  • CAS No: 220339-00-4
    Formula: C22H26N2O
    Molecular Weight: 334.45
  • IUPAC Name: N-(2-(2-benzyl-1H-indol-3-yl)ethyl)pentanamide
  • InChIKey: HDOIPCLEKCEANF-UHFFFAOYSA-N
  • SMILES: CCCCC(NCCC1=C(CC2=CC=CC=C2)NC3=C1C=CC=C3)=O

Biological Activity: N-Pentanoyl 2-benzyltryptamine is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. N-Pentanoyl 2-benzyltryptamine shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. N-Pentanoyl 2-benzyltryptamine can inhibit melatonin-induced enhancement of electrically-evoked responses[1][2].

Cat. No. Product Name Purity Description
HY-107628 N-Pentanoyl 2-benzyltryptamine N-Pentanoyl 2-benzyltryptamine is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. N-Pentanoyl 2-benzyltryptamine shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. N-Pentanoyl 2-benzyltryptamine can inhibit melatonin-induced enhancement of electrically-evoked responses.

References

[1]. Teh MT, et, al. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8. [Content Brief]
[2]. Ting KN, et, al. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br J Pharmacol. 1999 Jun;127(4):987-95. [Content Brief]

Keywords:

N-Pentanoyl 2-benzyltryptamine