2. Membrane Transporter/Ion Channel
  3. Sodium Channel Potassium Channel
  4. 98717-15-8

98717-15-8

Ropivacaine hydrochloride Chemical Structure

98717-15-8

Chemical Structure

  • Ropivacaine hydrochloride
  • CAS No: 98717-15-8
    Formula: C17H27ClN2O
    Molecular Weight: 310.86
  • IUPAC Name: (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
  • InChIKey: NDNSIBYYUOEUSV-RSAXXLAASA-N
  • SMILES: [H]Cl.O=C([C@H]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C

Biological Activity: Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is widely used for neuropathic pain management in vivo[1].

Cat. No. Product Name Purity Description
HY-B0563B Ropivacaine hydrochloride 99.49% Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for neuropathic pain management in vivo.

References

[1]. Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717. [Content Brief]
[2]. Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. [Content Brief]
[3]. Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb;28(1):81-6. [Content Brief]

Keywords:

Ropivacaine hydrochloride