2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. Casein kinase 1δ-IN-6

Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM. Casein kinase 1δ-IN-6 shows neuroprotective and anti-inflammatory properties both in vitro and in vivo. Casein kinase 1δ-IN-6 is a promising drug candidate and can be used for neurodegenerative diseases research.

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Casein kinase 1δ-IN-6 Chemical Structure

Casein kinase 1δ-IN-6 Chemical Structure

CAS No. : 1579991-01-7

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5 mg USD 360 In-stock
10 mg USD 540 In-stock
25 mg USD 940 In-stock
50 mg USD 1350 In-stock
100 mg USD 1850 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM. Casein kinase 1δ-IN-6 shows neuroprotective and anti-inflammatory properties both in vitro and in vivo. Casein kinase 1δ-IN-6 is a promising drug candidate and can be used for neurodegenerative diseases research.

Molecular Weight

370.78

Formula

C16H10ClF3N2OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC1=CC(Cl)=CC=C1)NC2=NC3=C(S2)C=C(C(F)(F)F)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (337.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6970 mL 13.4851 mL 26.9702 mL
5 mM 0.5394 mL 2.6970 mL 5.3940 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6970 mL 13.4851 mL 26.9702 mL 67.4254 mL
5 mM 0.5394 mL 2.6970 mL 5.3940 mL 13.4851 mL
10 mM 0.2697 mL 1.3485 mL 2.6970 mL 6.7425 mL
15 mM 0.1798 mL 0.8990 mL 1.7980 mL 4.4950 mL
20 mM 0.1349 mL 0.6743 mL 1.3485 mL 3.3713 mL
25 mM 0.1079 mL 0.5394 mL 1.0788 mL 2.6970 mL
30 mM 0.0899 mL 0.4495 mL 0.8990 mL 2.2475 mL
40 mM 0.0674 mL 0.3371 mL 0.6743 mL 1.6856 mL
50 mM 0.0539 mL 0.2697 mL 0.5394 mL 1.3485 mL
60 mM 0.0450 mL 0.2248 mL 0.4495 mL 1.1238 mL
80 mM 0.0337 mL 0.1686 mL 0.3371 mL 0.8428 mL
100 mM 0.0270 mL 0.1349 mL 0.2697 mL 0.6743 mL
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Casein kinase 1δ-IN-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Casein kinase 1δ-IN-61579991-01-7Casein Kinaseanti-inflammatory agentneurodegenerative diseasePDSH-SY5YGlial Primary CultureNeuroprotectiveParkinson’s diseaselead compoundInhibitorinhibitorinhibit

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