Caspase-3/7 activator 3

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Caspase-3/7 activator 3 is an effective activator of Caspase-3/7. Caspase-3/7 activator 3 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability.

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Caspase-3/7 activator 3 Chemical Structure

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Biological Activity
Purity & Documentation
References
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Description

Caspase-3/7 activator 3 is an effective activator of Caspase-3/7. Caspase-3/7 activator 3 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability^[1].

IC₅₀ & Target^[1]

Caspase-3

Caspase-7

In Vitro

Caspase-3/7 activator 3 (Compound 7g) inhibits Wi-38, Caco-2 and HepG-2 cells with IC₅₀ values of 17.077 µM, 0.064 µM, 0.065 µM, respectively^[1].
Caspase-3/7 activator 3 (0.06 μM; 72 h) significantly inhibits the expression of apoptosis inhibitor Bcl2 in Caco-2 cells (down-regulates Bcl2 by 0.087 folds). Caspase-3/7 activator 3 insignificantly effects the morphology of Caco-2 and HepG-2 cells^[1].
Caspase-3/7 activator 3 (0.064 µM; 72 h) has the potential to induces apoptosis of Caco-2 cells (the total apoptotic cell populations is 58.730 %)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	Caco-2 cells.
Concentration:	0.064 µM.
Incubation Time:	72 h.
Result:	Showed to promote cell apoptosis.

Molecular Weight

409.47

Formula

C₂₄H₂₇NO₅

SMILES

CCOC(C1=CC=C(C=C1)NC(C2(CCCCC2)OC(CC3=CC=CC=C3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ayoup MS, et al. Structure optimization of new tumor-selective Passerini α-acyloxy carboxamides as Caspase-3/7 activators. Sci Rep. 2022 Dec 27;12(1):22390. [Content Brief]