Caspofungin-d₄ diacetate  (Synonyms: MK-0991-d₄ diacetate; L-743872-d₄ diacetate)

Caspofungin-d₄ (acetate) is the deuterium labeled Caspofungin diacetate[1]. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan[2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1217.44

C₅₆H₉₂D₄N₁₀O₁₉

179463-17-3

Solid

White to off-white

CC(O)=O.O=C1N2[C@]([H])(C(N[C@H](NC([2H])(C([2H])(N)[2H])[2H])[C@H](O)C[C@H](NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)C(N[C@@]([H])([C@@H](C)O)C(N3[C@]([H])(C(N[C@@]([H])([C@@H]([C@@H](O)C4=CC=C(O)C=C4)O)C(N[C@]1([C@@H](CCN)O)[H])=O)=O)C[C@@H](O)C3)=O)=O)=O)[C@@H](O)CC2.CC(O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Flattery AM, et, al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7.  [Content Brief]

  [3]. Mojumder DK, et, al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803.  [Content Brief]