2. Anti-infection
  3. Fungal Antibiotic Bacterial
  4. Caspofungin diacetate

Caspofungin diacetate  (Synonyms: MK-0991 diacetate; L-743872 diacetate)

Cat. No.: HY-17006 Purity: 99.74%
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Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.

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Caspofungin diacetate Chemical Structure

Caspofungin diacetate Chemical Structure

CAS No. : 179463-17-3

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5 mg USD 66 In-stock
10 mg USD 96 In-stock
25 mg USD 192 In-stock
50 mg USD 348 In-stock
100 mg USD 540 In-stock
200 mg USD 780 In-stock
500 mg USD 1068 In-stock
1 g USD 1560 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Caspofungin diacetate:

Caspofungin diacetate Related Antibodies

Top Publications Citing Use of Products

    Caspofungin diacetate purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2016 Aug 12;39(3):939-949.  [Abstract]

    Arithmetic means±SEM (n=21) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Caspofungin (30-60 µg/mL).

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan[1][2].

    In Vivo

    Caspofungin diacetate (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain[1].
    Caspofungin diacetate (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Complement component 5-deficient DBA/2N mice[1]
    Dosage: 1, 2, 4 and 8 mg/kg
    Administration: Intraperitoneal injection; daily, for 7 days
    Result: Reduced the concentration of Candida load in the brain.
    Animal Model: Male C57BL/6 mice[2]
    Dosage: 0.41, 1.2, 2.5, 4.1, and 41 μM
    Administration: Intraperitoneal injection; for 5 weeks
    Result: Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.
    Clinical Trial
    Molecular Weight

    1213.42

    Formula

    C56H96N10O19
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC=C3O)O)=O)([H])[C@H](O)CCN)N(CC[C@@H]4O)[C@]4([H])C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)NCCN)=O.OC(C)=O.OC(C)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (82.41 mM)

    DMSO : 100 mg/mL (82.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8241 mL 4.1206 mL 8.2412 mL
    5 mM 0.1648 mL 0.8241 mL 1.6482 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.06 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (1.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (82.41 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.79%

    SDS (393 KB)

    COA (261 KB) HNMR (206 KB) LCMS (130 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.8241 mL 4.1206 mL 8.2412 mL 20.6029 mL
    5 mM 0.1648 mL 0.8241 mL 1.6482 mL 4.1206 mL
    10 mM 0.0824 mL 0.4121 mL 0.8241 mL 2.0603 mL
    15 mM 0.0549 mL 0.2747 mL 0.5494 mL 1.3735 mL
    20 mM 0.0412 mL 0.2060 mL 0.4121 mL 1.0301 mL
    25 mM 0.0330 mL 0.1648 mL 0.3296 mL 0.8241 mL
    30 mM 0.0275 mL 0.1374 mL 0.2747 mL 0.6868 mL
    40 mM 0.0206 mL 0.1030 mL 0.2060 mL 0.5151 mL
    50 mM 0.0165 mL 0.0824 mL 0.1648 mL 0.4121 mL
    60 mM 0.0137 mL 0.0687 mL 0.1374 mL 0.3434 mL
    80 mM 0.0103 mL 0.0515 mL 0.1030 mL 0.2575 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Caspofungin diacetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Caspofungin diacetate179463-17-3MK-0991 diacetateL-743872 diacetateFungalAntibioticBacterialantifungalfungal cell wallβ-(l,3)-D-glucanInhibitorinhibitorinhibit

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