2. Anti-infection
  3. Antibiotic Fungal Bacterial
  4. Caspofungin

Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.

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Caspofungin Chemical Structure

Caspofungin Chemical Structure

CAS No. : 162808-62-0

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Caspofungin Related Antibodies

Top Publications Citing Use of Products

    Caspofungin purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2016 Aug 12;39(3):939-949.  [Abstract]

    Arithmetic means±SEM (n=21) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Caspofungin (30-60 µg/mL).

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    Description

    Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan[1][2].

    In Vivo

    Caspofungin (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain[1].
    Caspofungin (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Complement component 5-deficient DBA/2N mice[1]
    Dosage: 1, 2, 4 and 8 mg/kg
    Administration: Intraperitoneal injection; daily, for 7 days.
    Result: Reduced the concentration of Candida load in the brain.
    Animal Model: Male C57BL/6 mice[2]
    Dosage: 0.41, 1.2, 2.5, 4.1, and 41 μM
    Administration: Intraperitoneal injection; for 5 weeks
    Result: Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.
    Clinical Trial
    Molecular Weight

    1093.31

    Formula

    C52H88N10O15
    CAS No.
    SMILES

    O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC=C3O)O)=O)([H])[C@H](O)CCN)N(CC[C@@H]4O)[C@]4([H])C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)NCCN)=O
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Caspofungin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Caspofungin162808-62-0MK-0991 L-743872MK0991MK 0991L743872L 743872L-743872AntibioticFungalBacterialantifungalfungal cell wallβ-(l,3)-D-glucanInhibitorinhibitorinhibit

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