2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Phospholipase Prostaglandin Receptor
  4. CAY10590

CAY10590 (GK115) is an inhibitor of secreted phospholipase A2 (sPLA2) and can be used for the research of chronic inflammatory kidney diseases.

For research use only. We do not sell to patients.

CAY10590 Chemical Structure

CAY10590 Chemical Structure

CAS No. : 1101136-50-8

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1 mg USD 85 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CAY10590 (GK115) is an inhibitor of secreted phospholipase A2 (sPLA2) and can be used for the research of chronic inflammatory kidney diseases[1].

IC50 & Target[1][2]

sPLA2

 

In Vitro

CAY10590 (GK115) (0-10 μM; 24 h) inhibits IL-1β/forskolin-stimulated PGE2 formation in mesangial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAY10590 Related Antibodies
Molecular Weight

347.49

Formula

C21H33NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCC[C@@H](NC(CCCCCCC1=CC=CC=C1)=O)CCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (57.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8778 mL 14.3889 mL 28.7778 mL
5 mM 0.5756 mL 2.8778 mL 5.7556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (242 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8778 mL 14.3889 mL 28.7778 mL 71.9445 mL
5 mM 0.5756 mL 2.8778 mL 5.7556 mL 14.3889 mL
10 mM 0.2878 mL 1.4389 mL 2.8778 mL 7.1945 mL
15 mM 0.1919 mL 0.9593 mL 1.9185 mL 4.7963 mL
20 mM 0.1439 mL 0.7194 mL 1.4389 mL 3.5972 mL
25 mM 0.1151 mL 0.5756 mL 1.1511 mL 2.8778 mL
30 mM 0.0959 mL 0.4796 mL 0.9593 mL 2.3982 mL
40 mM 0.0719 mL 0.3597 mL 0.7194 mL 1.7986 mL
50 mM 0.0576 mL 0.2878 mL 0.5756 mL 1.4389 mL
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CAY10590 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY105901101136-50-8GK115CAY 10590CAY-10590GK 115GK-115PhospholipaseProstaglandin Receptorglomerulonephritischronic inflammatory kidney diseasesmesangial cellsInhibitorinhibitorinhibit

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