2. GPCR/G Protein Neuronal Signaling MAPK/ERK Pathway NF-κB
  3. Cannabinoid Receptor p38 MAPK NF-κB
  4. CB1R antagonist 2

CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models.

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CB1R antagonist 2 Chemical Structure

CB1R antagonist 2 Chemical Structure

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CB1R antagonist 2 Related Antibodies

Top Publications Citing Use of Products

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CB1 CB2

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models[1].

Molecular Weight

386.49

Formula

C24H26N4O
SMILES

O=C(C1=NN(C2=CC=CC=C2)C(C3CCCCC3)=N1)N(C)/C=C\C4=CC=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CB1R antagonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB1R antagonist 2Cannabinoid Receptorp38 MAPKNF-κBNuclear factor-κBNuclear factor-kappaBRAW264.7allergic rhinitisInhibitorinhibitorinhibit

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HY-172409
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