2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. CCG-232601

CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma.

For research use only. We do not sell to patients.

CCG-232601 Chemical Structure

CCG-232601 Chemical Structure

CAS No. : 1922099-21-5

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Based on 1 publication(s) in Google Scholar

CCG-232601 Related Antibodies

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Description

CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma[1].

In Vitro

CCG-232601 inhibits SRE.L activity with an IC50 of 0.55 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCG-232601 Related Antibodies
In Vivo

CCG-232601 (50 mg/kg; i.g.; intracutaneous injections of bleomycin; daily for 14 days) inhibits bleomycin-induced skin fibrosis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

455.88

Formula

C24H20ClF2N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CN(C(C2=CC=CC(C3=CC=NC=C3)=C2)=O)CC(F)(F)C1)NC4=CC=C(Cl)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (87.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1936 mL 10.9678 mL 21.9356 mL
5 mM 0.4387 mL 2.1936 mL 4.3871 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.00%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1936 mL 10.9678 mL 21.9356 mL 54.8390 mL
5 mM 0.4387 mL 2.1936 mL 4.3871 mL 10.9678 mL
10 mM 0.2194 mL 1.0968 mL 2.1936 mL 5.4839 mL
15 mM 0.1462 mL 0.7312 mL 1.4624 mL 3.6559 mL
20 mM 0.1097 mL 0.5484 mL 1.0968 mL 2.7419 mL
25 mM 0.0877 mL 0.4387 mL 0.8774 mL 2.1936 mL
30 mM 0.0731 mL 0.3656 mL 0.7312 mL 1.8280 mL
40 mM 0.0548 mL 0.2742 mL 0.5484 mL 1.3710 mL
50 mM 0.0439 mL 0.2194 mL 0.4387 mL 1.0968 mL
60 mM 0.0366 mL 0.1828 mL 0.3656 mL 0.9140 mL
80 mM 0.0274 mL 0.1371 mL 0.2742 mL 0.6855 mL
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CCG-232601 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCG-2326011922099-21-5CCG232601CCG 232601RasHEK293T cellsBleomycindermal fibrosisantifibroticorally activeInhibitorinhibitorinhibit

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