2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. CD12681

CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis.

For research use only. We do not sell to patients.

CD12681 Chemical Structure

CD12681 Chemical Structure

CAS No. : 1952239-59-6

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CD12681 Related Antibodies

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Description

CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis[1].

IC50 & Target[1]

RORγ

 

In Vitro

CD12681 (compound 14) shows inhibition with IC50s of 44, >25, 9 µM for CYP 3A4, CYP 2D6, hERG, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CD12681 Related Antibodies
Molecular Weight

471.61

Formula

C25H33N3O4S
CAS No.
SMILES

O=S(C1=CC(NC(N2CC3CCOCC3)=O)=C2C=C1)(N(C4=CC=C(C)C=C4C)CC(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CD12681 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD126811952239-59-6CD 12681CD-12681RORRAR-related orphan receptorIL-17GAL4 cellsinflammatorypsoriasisInhibitorinhibitorinhibit

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