2. Immunology/Inflammation
  3. CD28
  4. CD80-IN-3

CD80-IN-3, a potent CD80 inhibitor, inhibits CD80/CD28 interaction with an EC50 of 630 nM and a Kd of 125 nM.

For research use only. We do not sell to patients.

CD80-IN-3 Chemical Structure

CD80-IN-3 Chemical Structure

CAS No. : 486449-65-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Solution
10 mM * 1 mL in DMSO USD 264 In-stock
Solid
5 mg USD 240 In-stock
10 mg USD 390 In-stock
25 mg USD 630 In-stock
50 mg USD 870 In-stock
100 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

CD80-IN-3 Related Antibodies

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Description

CD80-IN-3, a potent CD80 inhibitor, inhibits CD80/CD28 interaction with an EC50 of 630 nM and a Kd of 125 nM.

Molecular Weight

323.28

Formula

C17H10FN3O3
CAS No.
Appearance

Solid

Color

Light brown to yellow

SMILES

FC1=C(NC=C2C3=NN(C4=CC=C(C(O)=O)C=C4)C2=O)C3=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 35.71 mg/mL (110.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0933 mL 15.4665 mL 30.9329 mL
5 mM 0.6187 mL 3.0933 mL 6.1866 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0933 mL 15.4665 mL 30.9329 mL 77.3323 mL
5 mM 0.6187 mL 3.0933 mL 6.1866 mL 15.4665 mL
10 mM 0.3093 mL 1.5466 mL 3.0933 mL 7.7332 mL
15 mM 0.2062 mL 1.0311 mL 2.0622 mL 5.1555 mL
20 mM 0.1547 mL 0.7733 mL 1.5466 mL 3.8666 mL
25 mM 0.1237 mL 0.6187 mL 1.2373 mL 3.0933 mL
30 mM 0.1031 mL 0.5155 mL 1.0311 mL 2.5777 mL
40 mM 0.0773 mL 0.3867 mL 0.7733 mL 1.9333 mL
50 mM 0.0619 mL 0.3093 mL 0.6187 mL 1.5466 mL
60 mM 0.0516 mL 0.2578 mL 0.5155 mL 1.2889 mL
80 mM 0.0387 mL 0.1933 mL 0.3867 mL 0.9667 mL
100 mM 0.0309 mL 0.1547 mL 0.3093 mL 0.7733 mL
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CD80-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD80-IN-3486449-65-4CD28autoimmunerheumatoidarthritisCD80inflammatoryTcellInhibitorinhibitorinhibit

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