2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC CDK Apoptosis
  4. CDK/HDAC-IN-4

CDK/HDAC-IN-4 is a high selective dual cyclin-dependent kinase (CDK)/histone deacetylase (HDAC) inhibitor with IC50 values of 88.4 and 168.9 nM, respectively. CDK/HDAC-IN-4 exhibits antiproliferative capacities against hematological and solid tumor cells. CDK/HDAC-IN-4 also induces MV-4-11 cell Apoptosis and S cell cycle arrests. CDK/HDAC-IN-4 possesses a significant antitumor potency in the MV-4-11 xenograft model.

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CDK/HDAC-IN-4 Chemical Structure

CDK/HDAC-IN-4 Chemical Structure

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CDK/HDAC-IN-4 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

CDK/HDAC-IN-4 is a high selective dual cyclin-dependent kinase (CDK)/histone deacetylase (HDAC) inhibitor with IC50 values of 88.4 and 168.9 nM, respectively. CDK/HDAC-IN-4 exhibits antiproliferative capacities against hematological and solid tumor cells. CDK/HDAC-IN-4 also induces MV-4-11 cell Apoptosis and S cell cycle arrests. CDK/HDAC-IN-4 possesses a significant antitumor potency in the MV-4-11 xenograft model[1].

Molecular Weight

634.13

Formula

C34H32ClN9O2
SMILES

ClC1=CN=C(C=C1C2=CC=CC(NCC3(CCOCC3)C#N)=N2)NC4=CN(N=C4)CC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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CDK/HDAC-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK/HDAC-IN-4HDACCDKApoptosisHistone deacetylasesCyclin dependent kinaseantiproliferativehematological and solid tumor cellsS cell cycle arrestsantitumor potencyInhibitorinhibitorinhibit

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