2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. CDK Carbonic Anhydrase
  4. CDK2-IN-12

CDK2-IN-12 (compound 10b) is a potent CDK2 inhibitor, with an IC50 of 11.6 μM. CDK2-IN-12 inhibits hCA (carbonic anhydrase) isoforms I, II, IX and XII, with KI values of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity.

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CDK2-IN-12 Chemical Structure

CDK2-IN-12 Chemical Structure

CAS No. : 2410402-88-7

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CDK2-IN-12 Related Antibodies

Top Publications Citing Use of Products

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description

CDK2-IN-12 (compound 10b) is a potent CDK2 inhibitor, with an IC50 of 11.6 μM. CDK2-IN-12 inhibits hCA (carbonic anhydrase) isoforms I, II, IX and XII, with KI values of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity[1].

IC50 & Target

CDK2

11.6 μM (IC50)

CDK9

>12.5 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
15.1 μM
Compound: 10b
Antiproliferative activity against human MCF7 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
[PMID: 31972394]
MCF7 IC50
6.8 μM
Compound: 10b
Antiproliferative activity against human MCF7 cells measured after 48 hrs under normoxic condition by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs under normoxic condition by MTT assay
[PMID: 31972394]
MDA-MB-468 IC50
1.37 μM
Compound: 10b
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under normoxic condition by MTT assay
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under normoxic condition by MTT assay
[PMID: 31972394]
MDA-MB-468 IC50
3.03 μM
Compound: 10b
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay
[PMID: 31972394]
In Vitro

CDK2-IN-12 (compound 10b) exerts outstanding anti-proliferative activity against leukemia (CCRF-CEM, HL-60TB, K-562 and MOLT-4), non-small cell lung cancer (HOP-92), colon cancer (COLO 205, HCT-116 and SW-620), renal (ACHN) and breast (MDA-MB-468) cell lines with GI% (percentage growth inhibition) ranging from 80 to 100%[1].
CDK2-IN-12 displays much enhanced growth inhibitory activity, under normoxic and hypoxic conditions, against MDA-MB-468 (IC50 = 1.37 ± 0.07 and 3.03 ± 0.11 μM) than MCF-7 cells (IC50 = 6.80 ± 0.17 and 15.10 ± 0.82 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2-IN-12 Related Antibodies
Molecular Weight

447.47

Formula

C20H17N9O2S
CAS No.
SMILES

O=S(C1=CC=C(/N=N/C2=C3N=C(C4=CC=C(C)C=C4)C(C#N)=C(N)N3N=C2N)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK2-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-122410402-88-7CDKCarbonic AnhydraseCyclin dependent kinaseCarbonate dehydratasecarbonic anhydrase inhibitorsPyrazolopyrimidinesImidazopyrazolesCAN508Inhibitorinhibitorinhibit

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