CDK2-IN-9

Cat. No.: HY-144811: FAQs
Data Sheet Handling Instructions

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CDK2-IN-9 is a potent CDK2 inhibitor with an IC₅₀ of 0.63 µM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 induces apoptosis and cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma.

For research use only. We do not sell to patients.

CDK2-IN-9 Chemical Structure

CAS No. : 2919216-33-2

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

CDK2

0.63 μM (IC₅₀)

In Vitro

CDK2-IN-9 (compound 5c) shows antiproliferative activity with IC₅₀s of 3.03, 8.62, 62.52 µM for MDA-MB-435, SNB-75, WI-38 cells, respectively^[1].
CDK2-IN-9 (24 h) induces apoptosis and cell cycle arrest in S and G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	MDA-MB-435, SNB-75 cells
Concentration:	3.03for MDA-MB-435 cells, 8.62 for SNB-75 cells
Incubation Time:	24 h
Result:	Induced apoptosis in MDA-MB-435 and SNB-75 cells with the percent of the total apoptosis of 28.65 and 44.22%, respectively.

Cell Cycle Analysis^[1]

Cell Line:	MDA-MB-435, SNB-75 cells
Concentration:
Incubation Time:	24 h
Result:	Induced cell cycle arrest at S phase and G2/M.

Molecular Weight

441.89

Formula

C₂₁H₁₆ClN₃O₄S

CAS No.

2919216-33-2

SMILES

O=S(C1=CC=C(Cl)C=C1)(NN2C(COC3=CC=CC=C3)=NC4=C(C=CC=C4)C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mohammed ER, et al. Development of newly synthesised quinazolinone-based CDK2 inhibitors with potent efficacy against melanoma. J Enzyme Inhib Med Chem. 2022 Dec;37(1):686-700. [Content Brief]

CDK2-IN-9 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-92919216-33-2CDKApoptosisCyclin dependent kinaseantiproliferativeMDA-MB-435SNB-75 cellsmelanomaapoptosisS phaseG2/MInhibitorinhibitorinhibit

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