2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK4/6-IN-21

CDK4/6-IN-21 (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 has antitumor activity.

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CDK4/6-IN-21 Chemical Structure

CDK4/6-IN-21 Chemical Structure

CAS No. : 2102887-41-0

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Other Forms of CDK4/6-IN-21:

CDK4/6-IN-21 Related Antibodies

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Description

CDK4/6-IN-21 (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 has antitumor activity[1].

IC50 & Target

CDK4

3.88 nM (IC50)

CDK6

3.31 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1745 nM
Compound: 3d
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
[PMID: 31200237]
COLO 205 IC50
248 nM
Compound: 3d
Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
[PMID: 31200237]
MCF7 IC50
20.1 nM
Compound: 3d
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
[PMID: 31200237]
T47D IC50
19.4 nM
Compound: 3d
Antiproliferative activity against human T47D cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human T47D cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
[PMID: 31200237]
ZR-75-1 IC50
46.4 nM
Compound: 3d
Antiproliferative activity against human ZR-75-1 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
Antiproliferative activity against human ZR-75-1 cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
[PMID: 31200237]
Molecular Weight

504.58

Formula

C27H30F2N8
CAS No.
SMILES

FC1=C(C2=CC3=C(N=C(C)N3C4CC4)C(F)=C2)N=C(NC5=CC=C(CN(CCN(C)C)CC6)C6=N5)N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK4/6-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK4/6-IN-212102887-41-0CDKCyclin dependent kinaseInhibitorantitumorinhibitorinhibit

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