2. Cell Cycle/DNA Damage Stem Cell/Wnt PI3K/Akt/mTOR
  3. CDK GSK-3
  4. CDK5-IN-4

CDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5, with an IC50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α, GSK-3β, CDK9, and CDK2, with IC50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research.

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CDK5-IN-4 Chemical Structure

CDK5-IN-4 Chemical Structure

CAS No. : 1212711-91-5

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CDK5-IN-4 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

CDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5, with an IC50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α, GSK-3β, CDK9, and CDK2, with IC50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research[1].

IC50 & Target

GSK-3α

0.98 ± 0.0 μM (IC50)

GSK-3β

4.00 ± 1.3 μM (IC50)

CDK9

1.76 ± 0.3 μM (IC50)

CDK2

6.24 ± 2.8 μM (IC50)

CDK5

9.8 ± 2.29 μM (IC50)

Molecular Weight

449.48

Formula

C24H24FN5O3
CAS No.
SMILES

O=C(N[C@H]1CO[C@@H]2[C@H](CO[C@H]12)NC3=NC(C4=CC=CC(F)=C4)=CC=N3)NCC5=CC=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK5-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK5-IN-41212711-91-5CDKGSK-3Cyclin dependent kinaseGlycogen synthase kinase-3Glycogen synthase kinase 3U87-MGT98GU251-MGglioblastomaInhibitorinhibitorinhibit

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