2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-28

CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor(IC50＜5 nM). CDK7-IN-28 can inhibit proliferation of MDA-MB-468 cell line by blocking cell cycle and inhibiting DNA replication.

For research use only. We do not sell to patients.

CDK7-IN-28 Chemical Structure

CDK7-IN-28 Chemical Structure

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CDK7-IN-28 Related Antibodies

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  • Biological Activity

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Description

CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor(IC50＜5 nM). CDK7-IN-28 can inhibit proliferation of MDA-MB-468 cell line by blocking cell cycle and inhibiting DNA replication[1].

IC50 & Target[1]

CDK7/Cyclin H/MNAT1

＜5 nM (IC50)

cdk2/cyclin A

6224 nM (IC50)

CDK9/CyclinA

296 nM (IC50)

CDK13/Cyclin K

152 nM (IC50)

In Vitro

CDK7-IN-28 applies to MDA-MB-468 cells (IC50=2 nM), HepaRG cells (IC50 < 10 nM), NAl-H82 (IC50< 10 nM) has good antiproliferative activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-28 Related Antibodies

Cell Proliferation Assay

Cell Line:
Concentration:
Incubation Time:
Result:
Molecular Weight

460.50

Formula

C23H27F3N6O
SMILES

FC(F)(C1=CN=C(N=C1C2=CNC3=C2CCCN(C3=O)C4CC4)N[C@@H]5CNC6(CC5)CC6)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK7-IN-28 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-28CDKCyclin dependent kinaseCDK InhibitorMDA-MB-468 cellsInhibitorinhibitorinhibit

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CDK7-IN-28
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HY-158170
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