2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Bcl-2 Family Apoptosis
  4. CDKI-83

CDKI-83 is a potent CDK9 and CDK1 inhibitor with Ki values of 21 nM and 72 nM for CDK9/T1 and CDK1/B, respectively. CDKI-83 demonstrates effective anti-proliferative activity in human tumour cell lines with a GI50<1 μM. CDKI-83 effectively induces apoptosis in A2780 human ovarian cancer cells. CDKI-83 reduces phosphorylation at Ser-2 of RNA polymerase II (RNAPII) by inhibiting cellular CDK9 activity, and down-regulates Mcl-1 and Bcl-2. CDKI-83 has the potential for anti-cancer research.

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CDKI-83 Chemical Structure

CDKI-83 Chemical Structure

CAS No. : 1189558-88-0

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CDKI-83 Related Antibodies

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Description

CDKI-83 is a potent CDK9 and CDK1 inhibitor with Ki values of 21 nM and 72 nM for CDK9/T1 and CDK1/B, respectively. CDKI-83 demonstrates effective anti-proliferative activity in human tumour cell lines with a GI50<1 μM. CDKI-83 effectively induces apoptosis in A2780 human ovarian cancer cells. CDKI-83 reduces phosphorylation at Ser-2 of RNA polymerase II (RNAPII) by inhibiting cellular CDK9 activity, and down-regulates Mcl-1 and Bcl-2. CDKI-83 has the potential for anti-cancer research[1].

IC50 & Target[1]

CDK9/T1

21 nM (Ki)

CDK1/B

72 nM (Ki)

CDK2/E

232 nM (Ki)

CDK4/D

290 nM (Ki)

CDK7/H

405 nM (Ki)

Molecular Weight

485.58

Formula

C21H23N7O3S2
CAS No.
SMILES

N#CC1=CN=C(N=C1C2=C(N=C(S2)NC)C)NC3=CC=C(C(S(=O)(N4CCOCC4)=O)=C3)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDKI-83 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDKI-831189558-88-0CDKI83CDKI 83CDKBcl-2 FamilyApoptosisCyclin dependent kinaseanti-proliferativeA2780ovarian cancer cellSer-2RNA polymerase IIRNAPIIanti-cancerInhibitorinhibitorinhibit

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