Cefoperazone-d₅

Name: Cefoperazone-d 5
Brand: MedChemExpress
SKU: HY-B0210S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0210S Purity: 98.58%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cefoperazone-d₅ is deuterium labeled Cefoperazone. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity[1].

For research use only. We do not sell to patients.

Cefoperazone-d<sub>5</sub> Chemical Structure

Cefoperazone-d₅ Chemical Structure

CAS No. : 2410425-70-4

Size	Price	Stock	Quantity
1 mg	USD 3100	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cefoperazone-d₅:

Cefoperazone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cefoperazone-d₅ is deuterium labeled Cefoperazone. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity[1].

IC₅₀ & Target

β-lactam

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

650.70

Formula

C₂₅H₂₂D₅N₉O₈S₂

CAS No.

2410425-70-4

Unlabeled CAS

62893-19-0

Appearance

Solid

Color

White to off-white

SMILES

OC(C1=C(CSC2=NN=NN2C)CS[C@@]([C@@H]3NC([C@@H](C4=CC=C(C=C4)O)NC(N5C(C(N(CC5)C([2H])([2H])C([2H])([2H])[2H])=O)=O)=O)=O)([H])N1C3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (153.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.1 mg/mL (0.15 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5368 mL	7.6840 mL	15.3681 mL
5 mM	0.3074 mL	1.5368 mL	3.0736 mL
10 mM	0.1537 mL	0.7684 mL	1.5368 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.58%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB) HNMR (256 KB) RP-HPLC (306 KB) MS (862 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. N Matsubara, et al. In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin. Antimicrob Agents Chemother. 1979 Dec;16(6):731-5. [Content Brief]

[3]. Pedro H.Di Rocco, et al. Aerosol treatment with cefoperazone or gentamicin protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia. European Journal of Pharmaceutical Sciences Volume 1, Issue 6, June 1994, Pages 285-289.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	1.5368 mL	7.6840 mL	15.3681 mL	38.4202 mL
	5 mM	0.3074 mL	1.5368 mL	3.0736 mL	7.6840 mL
	10 mM	0.1537 mL	0.7684 mL	1.5368 mL	3.8420 mL
	15 mM	0.1025 mL	0.5123 mL	1.0245 mL	2.5613 mL
	20 mM	0.0768 mL	0.3842 mL	0.7684 mL	1.9210 mL
	25 mM	0.0615 mL	0.3074 mL	0.6147 mL	1.5368 mL
	30 mM	0.0512 mL	0.2561 mL	0.5123 mL	1.2807 mL
	40 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9605 mL
	50 mM	0.0307 mL	0.1537 mL	0.3074 mL	0.7684 mL
	60 mM	0.0256 mL	0.1281 mL	0.2561 mL	0.6403 mL
	80 mM	0.0192 mL	0.0961 mL	0.1921 mL	0.4803 mL
	100 mM	0.0154 mL	0.0768 mL	0.1537 mL	0.3842 mL