Cefotaxime-d₃ (Synonyms: Cefotaxim-d₃; HR-756-d₃)

Cat. No.: HY-W654101: FAQs
Data Sheet Handling Instructions

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Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.

For research use only. We do not sell to patients.

Cefotaxime-d<sub>3</sub> Chemical Structure

Cefotaxime-d₃ Chemical Structure

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Other Forms of Cefotaxime-d₃:

Cefotaxime Get quote
Cefotaxime-d₃ sodium Get quote

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Description

Molecular Weight

458.48

Formula

C₁₆H₁₄D₃N₅O₇S₂

Unlabeled CAS

63527-52-6

SMILES

[H][C@@]12N(C([C@H]2NC(/C(C3=CSC(N)=N3)=N\OC([2H])([2H])[2H])=O)=O)C(C(O)=O)=C(CS1)COC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (545.28 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1811 mL	10.9056 mL	21.8112 mL
5 mM	0.4362 mL	2.1811 mL	4.3622 mL
10 mM	0.2181 mL	1.0906 mL	2.1811 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185(1):45-9. [Content Brief]

[3]. Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44(2):142-7. [Content Brief]

[4]. E L Francke, et al. Use of cefotaxime, a beta-lactamase stable cephalosporin, in the therapy of serious infections, including those due to multiresistant organisms. Am J Med. 1981 Sep;71(3):435-42. [Content Brief]

[5]. Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42(1):71-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1811 mL	10.9056 mL	21.8112 mL	54.5280 mL
	5 mM	0.4362 mL	2.1811 mL	4.3622 mL	10.9056 mL
	10 mM	0.2181 mL	1.0906 mL	2.1811 mL	5.4528 mL
	15 mM	0.1454 mL	0.7270 mL	1.4541 mL	3.6352 mL
	20 mM	0.1091 mL	0.5453 mL	1.0906 mL	2.7264 mL
	25 mM	0.0872 mL	0.4362 mL	0.8724 mL	2.1811 mL
	30 mM	0.0727 mL	0.3635 mL	0.7270 mL	1.8176 mL
	40 mM	0.0545 mL	0.2726 mL	0.5453 mL	1.3632 mL
	50 mM	0.0436 mL	0.2181 mL	0.4362 mL	1.0906 mL
	60 mM	0.0364 mL	0.1818 mL	0.3635 mL	0.9088 mL
	80 mM	0.0273 mL	0.1363 mL	0.2726 mL	0.6816 mL
	100 mM	0.0218 mL	0.1091 mL	0.2181 mL	0.5453 mL

Cefotaxime-d₃ Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefotaxime-d₃Cefotaxim-d₃ HR-756-d₃Isotope-Labeled CompoundsAntibioticBacterialInhibitorinhibitorinhibit

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Cefotaxime-d3 (Synonyms: Cefotaxim-d3; HR-756-d3)

Other Forms of Cefotaxime-d3:

Cefotaxime-d3 Related Antibodies

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References

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Complete Stock Solution Preparation Table

Cefotaxime-d3 Related Classifications