Cephaloridine

Cat. No.: HY-B2072: FAQs
Data Sheet Handling Instructions

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Cephaloridine is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Cephaloridine hydrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Cephaloridine Chemical Structure

CAS No. : 50-59-9

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Other Forms of Cephaloridine:

Cephaloridine hydrate Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cephaloridine is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity^[1]^[2].

IC₅₀ & Target

β-lactam

In Vitro

Cephaloridine can inhibit Staphylococcus aureus penicillin-sensitive strains, penicillin-resistant strains, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium diphtheriae, Clostridium septicum, and so on, with MICs of 0.05-1 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cephaloridine (50-500 mg/kg; i.m.) exhibits dose-related nephrotoxicity in rabbits and monkeys^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rabbits and monkeys^[2]
Dosage:	50, 100, 200 and 500 mg/kg
Administration:	i.m.
Result:	Resulted in marked alteration in renal function and necrosis of proximal tubules at 200 and 500 mg/kg. Did not appear to cause renal injury at 50 and 100 mg/kg.

Molecular Weight

415.49

Formula

C₁₉H₁₇N₃O₄S₂

CAS No.

50-59-9

SMILES

O=C(C(N12)=C(C[N+]3=CC=CC=C3)CS[C@]2([H])[C@H](NC(CC4=CC=CS4)=O)C1=O)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. P. W. Muggleton, et al. Laboratory Evaluation of a New Antibiotic-Cephaloridine (Ceporin). Br Med J. 1964 Nov 14;2(5419):1234-7. [Content Brief]

[2]. Perkins RL, et al. Cephaloridine and cephalothin: comparative studies of potential nephrotoxicity. J Lab Clin Med. 1968 Jan;71(1):75-84. [Content Brief]

Cephaloridine Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cephaloridine50-59-9AntibioticBacterialantibacterialbroad-spectrumStaphylococcusCorynebacteriumClostridiumnephrotoxicityInhibitorinhibitorinhibit

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